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KMID : 0351619740150010263
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Kyungpook Medical Journal
1974 Volume.15 No. 1 p.263 ~ p.277
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Soluble Antigen Induced Morphologic Changes of Antibody Synthetic Organelles in the Rabbit Popliteal Lymphnode
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Abstract
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The imiunocyte types with their appearing time and organelle changes related to the protein synthes is the pepliteal lymph nodes were observed following the injection cf the mixture of bovine gamma globulin and complete Freund´s adjuvant, irl the state of the water in oil emulsion, into the foot pad of the rabbits.
The results were as follow:
Aatigen stimuli induced appearance cf the immunobIasts, which were rich in free. ribosemes, and a few dilated rER, and then followed by the vesicular or vacuolar rER containing plasmablast and lamellated rER containing .*nature plasma cells appearance. These cells started to appear fre~1 `?4 hours af~er the stimulation to the peak on 2 to 3 days later.
Flattered sacs or rER were fragmented to vesicular form after antigenic stimulus. As their function ;iecr~asing, they were fused to vacuolar form followed by the flattened sacs. Vesicuiations of rER iv~re initiated since 24 hours later and reached to the peak ? to 3 days after the ~timulatien. At the s~ .e time vacuolar and vesicular components of Golgi complex were increased in cumbers. GERL were also increased in maturing face of GoIgi complex, but secretory graau´_es were not fund. The other observed findings were the increase of sER and lysosome, irregularity er nuclear margin and occurence of fibrillar component in the nucleolonema, a these charges were thought to be secondary effects of activation of secretory function.
These results suggest that so secretory function of the antibody forming ce1_Is activate, as flattened rER was changed to vesicles folic-ed by vacuolization, and returned to flattened sacs along the antigenic stimulus subsidence. While their secretory routes were obscure, antibody secretion witl:ou forming secretory granules was considred most possibly.
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KEYWORD
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